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coumarin derivative

" in MedChemExpress (MCE) Product Catalog:

39

Inhibitors & Agonists

5

Fluorescent Dye

13

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2

Isotope-Labeled Compounds

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0947

    (-)-Praeruptorin B

    Others Inflammation/Immunology
    (-)-Anomalin ((-)-Praeruptorin B) is a coumarin derivative isolated from the root of Angelica anomala .
    (-)-Anomalin
  • HY-D0039

    Fluorescent Dye Others
    3-Cyanoumbelliferone is a coumarin derivative, acting as molecular probe and fluorescent dye. 3-Cyanoumbelliferone is also a macrophage migration inhibitory factor (MIF) tautomerase inhibitor with a Ki of 2.9 μM .
    3-Cyanoumbelliferone
  • HY-N8791

    Others Others
    Qianhucoumarin G is a natural coumarin derivative found in Ligustici Radix .
    Qianhucoumarin G
  • HY-N11791

    Others Others
    Qianhucoumarin B is a coumarin derivative. Qianhucoumarin B can be isolated from from the traditional Chinese medicine Qianhu, roots of Peucedanum praeruptorum .
    Qianhucoumarin B
  • HY-163397

    Fungal Infection
    Antibacterial agent 196 (compound 6b) is a coumarin derivative containing oxime ether structure, and shows antifungal activity, with the EC50 of 0.46 μg/mL against Rhizoctonia solani .
    Antibacterial agent 196
  • HY-121930

    Fluorescent Dye Inflammation/Immunology
    Coumarin 6H, a Coumarin (Coumarin (HY-N0709)) derivative, is a laser dye. The fluorescence emission of Coumarin 6H can be enhanced by hydrogen bonding interactions .
    Coumarin 6H
  • HY-A0145

    Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K.
    Phenprocoumon
  • HY-N6657

    Others Cancer
    7-Hydroxy-4-methyl-8-nitrocoumarin is a coumarin derivative .
    7-Hydroxy-4-methyl-8-nitrocoumarin
  • HY-128410

    Others Inflammation/Immunology
    4-Phenyl-7,8-dihydroxycoumarin is a coumarin derivative and can be used for bronchiectasiss research .
    4-Phenyl-7,8-dihydroxycoumarin
  • HY-109714

    Others Inflammation/Immunology
    3,4-Benzocoumarin is a kind of the expanded structure of coumarin derivatives.Coumarin is a chemical compound in the benzopyrone chemical class that can be found in many natural species. Coumarins possess variety of biological activities and unique photophysical properties . 3,4-Benzocoumarin, a AOH‐like compound , has the sensibility of the antibody with an IC50 of 919.2 ng/mL .
    3,4-Benzocoumarin
  • HY-121770

    Others Others
    Rutarin is a Coumarin (HY-N0709) derivative, that can be isolated from the aerial parts of the plant Atalantta racemosa .
    Rutarin
  • HY-155095

    Others Infection
    DNA polymerase-IN-4 (Compd 5c), a coumarin derivative, has antiretroviral activity with IC50 value of 134.22 μM .
    DNA polymerase-IN-4
  • HY-101887
    Calcein Blue
    1 Publications Verification

    Fluorescent Dye Others
    Calcein Blue, a membrane-impermeant fluorescent dye, is a coumarin derivative that contains an iminodiacetic acid structure. Calcein Blue is also a metallofluorochromic indicator .
    Calcein Blue
  • HY-Y1298
    Methyl acetylacetate
    1 Publications Verification

    Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate

    Endogenous Metabolite Metabolic Disease
    Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives .
    Methyl acetylacetate
  • HY-129605

    Oxidative Phosphorylation Mitochondrial Metabolism Infection
    Ferulenol, a sesquiterpene prenylated coumarin derivative, specifically inhibits succinate ubiquinone reductase at the level of the ubiquinonecycle. Ferulenol shows good antimycobacterial activity and haemorrhagic action .
    Ferulenol
  • HY-149828

    Methylenetetrahydrofolate Dehydrogenase (MTHFD) Cancer
    MTHFD2-IN-4, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. MTHFD2-IN-4 can be used in research of cancer .
    MTHFD2-IN-4
  • HY-149828A

    Methylenetetrahydrofolate Dehydrogenase (MTHFD) Cancer
    MTHFD2-IN-4 sodium, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. MTHFD2-IN-4 sodium can be used in research of cancer .
    MTHFD2-IN-4 sodium
  • HY-155094

    DNA/RNA Synthesis Others
    DNA polymerase-IN-3 (Compd 5b) is a coumarin derivative that exhibits inhibitory activity against Taq DNA polymerase and can be used in proliferative disease research .
    DNA polymerase-IN-3
  • HY-N7650

    Biochemical Assay Reagents Others
    Dihydroseselin is a derivative of 7-hydroxycoumarin (HY-N0573). 7-hydroxycoumarin, a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent
    Dihydroseselin
  • HY-W027544

    Fluorescent Dye Others
    MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities .
    MCA
  • HY-N4102

    Fungal Bacterial Infection
    5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities .
    5,7-Dihydroxy-4-methylcoumarin
  • HY-N4288

    Glutathione Peroxidase Inflammation/Immunology Cancer
    4-Methylesculetin is an orally active natural coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity and reduces IL-6 level .
    4-Methylesculetin
  • HY-W014081

    Ethyl 2-oxo-2H-chromene-3-carboxylate

    Others Others
    Ethyl 3-coumarincarboxylate is a coumarin derivative. Ethyl 3-coumarincarboxylate can be used as a pseudo-template to give a molecularly imprinted polymer (MIP) that has a fairly specific recognition capability for aflatoxins .
    Ethyl 3-coumarincarboxylate
  • HY-D0092

    Cytochrome P450 Others
    7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6 .
    7-Ethoxy-4-methylcoumarin
  • HY-155092

    DNA/RNA Synthesis Others
    DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, exhibits inhibitory activity against Taq DNA polymerase with IC50 of 48.25 μM , which can be used in value-added disease research .
    DNA polymerase-IN-2
  • HY-Y1298R

    Acetoacetate methyl ester (Standard); Methyl 3-oxobutanoate (Standard); Methyl acetoacetate (Standard)

    Endogenous Metabolite Metabolic Disease
    Methyl acetylacetate (Standard) is the analytical standard of Methyl acetylacetate. This product is intended for research and analytical applications. Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives .
    Methyl acetylacetate (Standard)
  • HY-W030319

    Fluorescent Dye Others
    Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate, a natural coumarins derivative, is exploited for the synthesis of the switchable fluorescent substrates to be used in bacterial enzyme detection .
    Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate
  • HY-D1085

    Fluorescent Dye Others
    AMCA-X-SE is a coumarin derivative that generates fixed blue fluorescence and an NHS-activated ester that forms stable amide bonds with primary amine groups. It is used as a reactive dye for labeling amino groups of peptides, proteins, and oligonucleotides. Maximum excitation/emission wavelength: 354/442 nm .
    AMCA-X SE
  • HY-146305

    Glucosidase Infection Cardiovascular Disease Others Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
    α-Glucosidase-IN-4 is a reversible and mixed type α-glucosidase inhibitor with an IC50 of 12.98 μM, a KI of 27.02 μM, and a KIS of 13.65 μM, respectively .
    α-Glucosidase-IN-4
  • HY-N9630

    Others Others
    Qianhucoumarin C is a coumarin derivative, which can be isolated from the roots of Peucedanum praeruptorum. Qianhuoumarin C has been studied for potential medicinal properties, including anti-inflammatory, antioxidant and anticancer effects. Qianhucoumarin C is an important ingredient in a variety of industrial processes, especially in the production of pharmaceuticals and herbal medicines .
    Qianhucoumarin C
  • HY-N4286

    Apoptosis Cancer
    4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation .
    4-Methyldaphnetin
  • HY-D0128

    7-Methoxy-4-methylcoumarin

    Bacterial Infection
    4-Methylherniarin (7-Methoxy-4-methylcoumarin) is a coumarin derivative and fluorescent label, has an antimicrobial activitiy against both gram positive and gram negative bacterial stains. 4-Methylherniarin displays good activity against B. subtilis and S.sonnei with IC50 values of 11.76 μg/ml and 13.47 μg/ml .
    4-Methylherniarin
  • HY-N6856

    4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .
    4-Hydroxycoumarin
  • HY-W027544S

    7-Methoxy-d3-2-oxo-2H-1-benzopyran-4-acetic acid; 7-Methoxy-d3-2H-chromen-2-one-4-acetic acid

    Isotope-Labeled Compounds Others
    (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d3 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3].
    (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d3
  • HY-163457

    Aminoacyl-tRNA Synthetase Parasite Infection
    Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC50 values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties .
    Antileishmanial agent-27
  • HY-76779

    Others Cancer
    4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII .
    4-(Chloromethyl)-7-hydroxycoumarin
  • HY-157992

    Interleukin Related Caspase Lactate Dehydrogenase Reactive Oxygen Species Neurological Disease Inflammation/Immunology
    LM-021 is a coumarin-chalcone derivative with anti-aggregatory, antioxidant, neuroprotective and anti-inflammatory properties which suppresses nitric oxide (NO), IL-1β, IL-6, TNF-α production, CD68 antigen (CD68) and histocompatibility-2 (MHCII) expression. LM-021 also attenuates the increase of caspase 1 activity, lactate dehydrogenase release and ROS level. LM-021 can be used for neurological research .
    LM-021
  • HY-N0281
    Daphnetin
    2 Publications Verification

    7,8-Dihydroxycoumarin

    EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species Caspase Bcl-2 Family PARP Parasite Inflammation/Immunology Cancer
    Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .
    Daphnetin
  • HY-W027544S1

    5-(Dimethyl-d6-amino)-N-(prop-2-ynyl)naphthalene-1-sulfonamide

    Isotope-Labeled Compounds Others
    (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6

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